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Pattern Examiner's Benefits
 

Fast and Comprehensive

Pattern ExaminerTM achieves a delicate and important balance between completeness of a search and performance, a common issue in gene interaction analysis on WGA studies that can involve up to one million markers. It intelligently identifies the most likely places that positive gene interactions might occur and then performs complete search in those places to solidify the findings. As a result, potential gene interactions that are supported by multiple lines of evidence can be identified in unprecedented short amount of time.

Powerful with Build-in Validation

Power analysis suggests that Pattern ExaminerTM has more power than a converntional method to detect gene interactions, thanks to the efficient pattern discovery algorithm and a multuple testing correction scheme that is sufficient but less stringent than the Bonferroni correction. In addition, instead of relying on a single statistically significant evidence to report a positive result, Pattern ExaminerTM can provide correlation between positive signals obtained from marker-based analyses and signals obtained from haplotype-based analyses. Furthermore, Monte Carlo simulations can be easily run to validate the findings.

Automated Disease Model Prediction

Disease model prediction is an important step when investigating disease-correlated gene interactions. Taking into consideration the marker allele information in a significant pattern, Pattern ExaminerTM automatically report possible disease model (recessive-recessive, recessive-dominant, etc.) that underlines a disease-correlated gene interaction.

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